e/Antisense RNA

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has glosseng: Antisense RNA is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery. This effect is therefore stoichiometric. An example of naturally occurring mRNA antisense mechanism is the hok/sok system of the E.coli R1 plasmid. Antisense RNA has long been thought of as a promising technique for disease therapy; the only such case to have reached the market is the drug fomivirsen. One commentator has characterized antisense RNA as one of "dozens of technologies that are gorgeous in concept, but exasperating in [commercialization]". Generally, antisense RNA still lack effective design, biological activity, and efficient route of administration.
lexicalizationeng: Antisense rna
instance of(noun) (biochemistry) any of various macromolecules composed of nucleotide chains that are vital constituents of all living cells
nucleic acid
Meaning
Czech
has glossces: Antisense RNA (aRNA) je RNA, která je komplementární k určitému řetězci mRNA. Znamená to, že místo adeninu má antisense RNA uracil, místo uracilu adenin, místo guaninu cytosin a místo cytosinu guanin. Například k řetězci „AGUCAUG“ je komplementární řetězec „UCAGUAC“.
lexicalizationces: Antisense RNA
German
has glossdeu: Die Antisense-RNA (aRNA) ist eine einzelsträngige RNA, die komplementär zur Messenger-RNA (mRNA) ist.
lexicalizationdeu: Antisense-RNA
Dutch
has glossnld: Een anti-sense gen is een gen dat door genetische manipulatie in omgekeerde volgorde weer in het DNA is gezet. Hierdoor wordt de werking van het normale niet veranderde gen geblokkeerd. Het woord sense wordt gebruikt om de richting van het niet veranderde gen aan te geven.
lexicalizationnld: anti-sense gen
Russian
has glossrus: Антисмысловые РНК (англ. ) это одноцепочечные РНК, которые комплементарны мРНК, транскрибируемой в клетке. Антисмысловые РНК вводят в клетки для ингибирования трансляции комплементарных мРНК за счет того, что антисмысловые РНК спариваются с мРНК-мишенью и физически препятствуют формированию трансляционного комплекса. Данный эффект поэтому является стехиометрическим.
lexicalizationrus: антисмысловые РНК
Slovenian
has glossslv: Protismiselna RNK je enovijačna molekula RNK, ki je komplementarna informacijski RNK (mRNK). Po vezavi protismiselne RNK na mRNK je preprečeno prevajanje mRNK na ribosomih in posledično ne nastaja ustrezna beljakovina, za katero nosi mRNK zapis. Zato je uporaba protismiselne RNK za določeno mRNK ena izmed potencialnih možnosti v genski terapiji bolezni, kjer je vzrok bolezenskega stanja nastajanje določene beljakovine.
lexicalizationslv: Protismiselna RNK
Media
media:imgAntisensedna.jpg

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