e/Epsin

Information
has gloss	eng: Epsins are the family of membrane proteins that are important in creating the needed membrane curvature. Epsins contribute to various needed membrane deformations like endocytosis and block vesicle formation during mitosis. Epsins has many different domains to interact with various proteins related to endocytosis. At its N-terminus is an ENTH domain situated that binds Phosphatidylinositol (4,5)-bisphosphate what means it binds a lipid of biological membranes. Further this is a possible site for cargo-binding. In the middle of the epsin sequence are two UIM's (ubiquitin-interacting motifs) located. The C-terminus contains multiple binding sites, for example for clathrin and AP2 adaptors. Because of that Epsins are able to bind to a membrane with a specific cargo and connect it with the endocytosis machinery, so you may understand Epsin as something like a Swiss army knife for endocytosis.
lexicalization	eng: Epsin
instance of	c/Peripheral membrane proteins