e/Molecular mimicry

Information
has gloss	eng: Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these “peptide mimic” specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders.
lexicalization	eng: molecular mimicry
instance of	e/Infectious disease

Meaning
Czech
has gloss	ces: Molekulární mimikry či také antigenní mimikry je napodobování jedné molekuly molekulou jinou. To se může stát náhodou, ale mnohdy dochází k tomuto jevu u molekul některých parazitů, kteří tak napodobují molekuly svého hostitele a unikají tím jeho imunitní obraně.
lexicalization	ces: Molekulární mimikry
German
has gloss	deu: Molekulare Mimikry bezeichnet das Verbergen bakterieller, viraler oder parasitärer Oberflächenmoleküle vor der Immunabwehr des Wirts. Diese Moleküle werden deshalb nicht vom Immunsystem anerkannt, weil ähnliche oder gleiche Substanzen auch im Wirt vorkommen. Da der Wirtsorganismus gegen die eigenen Moleküle im Normalfall keine Antikörper bildet, werden diese Bestandteile des Pathogens nicht als Antigen erkannt.
lexicalization	deu: Molekulare Mimikry
Italian
has gloss	ita: Il mimetismo molecolare è una delle strategie di mimetismo usate dai microrganismi per sfuggire agli attacchi dell'organismo ospite.
lexicalization	ita: mimetismo molecolare

Media
media:img	3 ways for T cell tolerance2.DL.JPG
media:img	Streptococcus pyogenes 01.jpg