| has gloss | eng: History The cell line SH-SY5Y is a thrice-cloned neuroblastoma, originally from SK-N-SH and first reported in 1978. A neuroblast-like subclone of SK-N-SH, named SH-SY, was subcloned as SH-SY5, which was subcloned again as SH-SY5Y . The cloning process is essentially artificial selection, involving expansion of individual cells or a small group of cells that express a particular phenotype of interest. This cell line is genetically female (has two X chromosomes, but no Y), as the original line was established in 1970 from a bone marrow biopsy of a metastatic neuroblastoma site in a four year-old female . |
