| Information | |
|---|---|
| has gloss | eng: The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. In IgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody's two heavy chains; IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2–4) in each polypeptide chain. The Fc regions of IgGs bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. Additionally, small amounts of these N-glycans also bear bisecting GlcNAc and α-2,6 linked sialic acid residues. |
| lexicalization | eng: Fragment crystallizable region |
| instance of | (noun) any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response antibody |
| Meaning | |
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| Indonesian | |
| has gloss | ind: Fragmen konstan ( |
| lexicalization | ind: fragmen konstan |
| Italian | |
| has gloss | ita: Il frammento Fc, o frammento cristallizzabile, è una delle due porzioni che si ottengono per clivaggio di un anticorpo tramite speciali enzimi proteolitici (pepsina, papaina). Lanticorpo viene tagliato da questi enzimi a livello del punto di congiunzione tra i tre bracci e si divide in tre frammenti: *due frammenti Fab, o "frammento legante lantigene", *un frammento Fc, o "frammento cristallizzabile". |
| lexicalization | ita: frammento Fc |
| Russian | |
| has gloss | rus: Кристаллизующийся фрагмент иммуноглобулина (Fc, fragment crystallizable region, Fc region) — это концевая часть молекулы иммуноглобулина, которая взаимодействует с Fc-рецептором на поверхности клетки и с некоторыми белками системы комплемента. Данное свойство позволяет антителам активировать иммунную систему. Fc участок IgG, IgA и IgD изотипов состоит их двух одинаковых белковых фрагментов, соответственно, второго и третьего константных доменов двух тяжелых цепей; в случае изотипов IgM и IgE Fc содержит три константных домена тяжелых цепей (домены CH 2-4) в каждой полипептидной цепочке. |
| lexicalization | rus: Fc |
| Media | |
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| media:img | 2fab fc.png |
| media:img | F ab2 pFc.png |
| media:img | Fab fcfragment colors.png |
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